Do you know what are the NMN biosynthesis methods?

nmn biosynthesis refers to the process of converting precursors into nmn through a series of enzymatic reactions in the cell.

Here is some information about nmn biosynthesis:

1. Intracellular synthesis:

The synthesis of nmn in the cell requires the participation of a variety of enzymes, using glucose as the main energy source to convert into nmn precursor substances, including nmn itself.

2. nmn synthesis in experiments:

In the laboratory, nmn can be manufactured by techniques such as gene editing or fermentation.

For example, when Professor Shinichiro Imai's research team at the University of Washington fed nmn to mice, they found that their plasma nmn levels rose rapidly within 10 minutes, and then quickly fell back, while plasma nad+ levels also gradually increased.

3. Mechanism of action of nmn:

One of the keys to nmn's role in the body is to help produce atp (adenosine triphosphate).

atp is the "energy currency" shared by all organisms and plays a key regulatory role in cell metabolism, inflammation, damage repair and other aspects.

In addition, nmn also has various biochemical interactions with more than 400 proteins, including a family of proteins called sirtuins that play key regulatory roles in cell metabolism, inflammation, and damage repair.

The full name of sirtuins is "silence information regulator", which is composed of seven enzymes sirt1-sirt7. They all require nad+ as a coenzyme to function.

4. The way to ingest nmn:

Many common foods in life contain nmn, but the content is relatively low.

nmn in humans is mainly synthesized by nam (niacinamide) and nr (niacinamide riboside).

It should be noted that the current research on nmn is still in progress, and its mechanism and effect need further research and verification.

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