How does NMN improve sleep quality in the elderly?

The body clock controls the body's circadian rhythm, which affects the depth and duration of sleep.

The core oscillation mechanism of the biological CLOCK consists of a heterodimer activator (CLOCK:BMAL1), which is regulated through a transcription-translation feedback loop.

The metabolism of NAD+ is regulated by the circadian clock, and NAD+ also regulates the circadian clock by affecting the activity of SIRT1 protein, an NAD+ dependent deacetylase.

SIRT1 accelerates the breakdown of PER protein, a key component of the biological clock, thereby reducing the inhibition of BMAL1 by PER, allowing the biological clock to oscillate in a cycle.

NMN is a precursor of NAD+, and exogenous intake of NMN can increase the level of NAD+ in the body.

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This process helps boost SIRT1 activity, which helps regulate sleep disorders and disrupted body clocks in aging populations.

After increasing the level of NAD+, the body clock becomes more adaptable, helping to restore normal circadian rhythms, thereby improving sleep quality.

Some studies indicate that NMN can significantly shorten the time to fall asleep, increase the time of rapid eye movement (REM) and deep sleep, and reduce the proportion of light sleep and wake frequency.

In addition to NMN, other methods can be taken to improve sleep quality, such as maintaining a regular schedule, avoiding excessive excitement or nervousness before going to bed, and creating a comfortable sleep environment.

The mechanism of NMN to improve sleep is mainly based on the increase of NAD+ level and the regulation of biological clock.

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