How much do you know about NAD+, one of most important coenzymes in human body?

NAD is one of the most important coenzymes in the human body, also known as Coenzyme I, the full name of nicotinamide adenine dinucleotide (nicotinamide dinucleotide).

NAD+ was first discovered and named in 1904 by British biochemist Sir Arthur Harden (1865-1940), for which he was awarded the 1929 Nobel Prize in Chemistry.

Why supplement NAD+?

NAD+ is widely present in every cell of the human body. As a key metabolite and coenzyme in a variety of metabolic pathways, NAD+ plays an important role in mediating and participating in various biological processes. More than 300 enzymes must rely on NAD + to work normally.

However, with increasing age, the level of NAD + in the body will rapidly decline.

Every 20 years or so, its levels decrease by 50%.

By age 40, the amount of NAD+ in the human body is only 25% of what it was in childhood.

Once the level of NAD + is reduced, there is no way to establish effective communication between cells, and cell energy will decrease, which will lead to a series of corresponding changes.

As we all know, there are two main causes of cellular senescence.

One is a lack of energy supply to cells, which reduces the efficiency of collagen synthesis, resulting in wrinkles and sagging skin.

The second is DNA damage, and when this damage accumulates to a certain extent, the cell is likely to completely deviate from its normal course of operation.

Role and efficacy of NAD+

1. Anti-aging

NAD+ maintains chemical communication between the nucleus and mitochondria, and weakened communication is an important cause of cellular aging.

NAD+ can remove the increasing error DNA code in the process of cell metabolism, maintain the normal expression of genes, maintain the normal operation of cells, and slow down the aging of human cells.

2. Repair genes

NAD+ is the only substrate for the DNA repair enzyme PARP, which is involved in DNA repair to help repair damaged DNA and cells, reduce the chance of cell mutation, and prevent the occurrence of cancer.

3. Activate all longevity proteins

NAD+ can activate all seven longevity proteins, so NAD+ has a more important impact on anti-aging and life extension.

4. Boost your immune system

NAD+ strengthens the immune system and enhances cellular immunity by selectively influencing and regulating the survival and function of T cells.

5. Provide energy

The mitochondria in human cells are the power plants of the cells, and NAD+ is an important coenzyme in the mitochondria that generates the energy molecule ATP, converting nutrients into energy needed by the human body.

6. Boost your metabolism

Metabolism is the sum of various chemical reactions in the body, the body will continue to carry out the exchange of matter and energy, when this exchange stops, the body's life will also end.

Professor Anthony and his research team at the University of California found that NAD+ can effectively improve the slowing down of cell metabolism associated with aging, thereby improving people's physical health and extending life span.

How to supplement NAD+?

When NAD+ is involved in DNA repair, it becomes a consumable, aging, environmental radiation and other factors will cause the accumulation of DNA damage, resulting in a decrease in the concentration of NAD+ in the cell, how to supplement NAD+ has naturally become the focus of scientific research.

In the traditional understanding, due to the large molecular weight of NAD+, it is difficult to enter the cell through the membrane, so exogenous supplementation is mainly based on its precursor substances, such as NMN, NDAH, NR, etc., but the latest research results may be able to break this rule and solve the bottleneck that NAD+ cannot be directly supplemented.

Current research shows that the most obvious way to supplement NAD+ is to supplement NAD directly.

To sum up, NAD+ plays a vital role in human health.

It is not only a necessary substance for cellular respiration, but also a key component of many vital substances in the human body, and improving the level of NAD+ helps to maintain physical and mental health.

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